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WO/2021/211058A1 |
The present invention relates, in general terms, to a method of extracting resin glycoside from a plant selected from the Convolvulaceae family. The resin glycosides can be extracted from Ipomoea batatas and/or Ipomoea aquatic. The prese...
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WO/2021/203409A1 |
A novel non-hygroscopic low-variability crystalline form for treatment of hepatitis C. The novel crystalline form T has a simple crystallization process, is easy for industrial production, and has no hygroscopicity. The use of a suitable...
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WO/2021/207085A1 |
Provided herein are methods for site selective chemical modification of an oligonucleotide comprising immobilizing the oligonucleotide on an inert resin to form oligonucleotide-resin complex; and contacting the oligonucleotide-resin comp...
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WO/2021/206182A1 |
The present invention pertains to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein in formula (1), R1 to R3 each independently are a predetermined amino group, a predetermined amide group, or a...
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WO/2021/196105A1 |
The present invention relates to the field of medicines, in particular to an anti-tumor effective component of Hedyotis diffusa, a preparation method therefor and the use thereof. Provided in the present invention is the use of one or a ...
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WO/2021/202883A1 |
Disclosed herein are genetically modified microorganisms and related methods for the enhanced production and export of oligosaccharides. The microorganisms described herein express major facility superfamily proteins such as CDT-1, which...
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WO/2021/198958A1 |
A nucleic acid polymer comprising 8 to 50 nucleoside subunits linked by intersubunit linkages, wherein the nucleic acid polymer comprises (A) one or more 3'-5' thiophosphoramidate intersubunit linkage and the remaining intersubunit linka...
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WO/2021/201669A1 |
Disclosed herein is a polymeric amphoteric surfactant compound of formula (I).
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WO/2021/196349A1 |
An organic acid salt of nicotinamide riboside; the organic acid is selected from malic acid, citric acid, royal jelly acid, and so on, and the molar ratio of nicotinamide riboside to organic acid is 1:2 or 1:1. A compound composition of ...
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WO/2021/198160A1 |
The present invention relates to a process for preparing a compound of formula (X), wherein said process is suitable for large scale synthesis.
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WO/2021/198883A1 |
Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or ...
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WO/2021/198040A1 |
The invention relates to a method for preparing 3'-O-amino-2'-deoxyribonucleoside- 5'-triphosphates with reduced 3'-hydroxy-2'-deoxyribonucleoside-5'-triphosphate contamination by converting 3'-(N-acetone-oxime)-2'-deoxynucleoside tripho...
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WO/2021/186258A1 |
Various methods are provided for providing a solid HMO product, said methods including drum-drying, belt drying, preferably vacuum bed drying, or granulation. Solid HMO products are obtained via said methods, as well as solid HMO product...
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WO/2021/186328A1 |
Provided herein are novel synthetic routes to amines through an oxime intermediate, e.g., 3'-N nucleosides and novel and intermediate compounds produced during these synthetic procedures.
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WO/2021/183750A2 |
The present disclosure generally describes methods of preparing l'-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (Il-a) in a flow reactor.
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WO/2021/181349A1 |
The invention relates to a method for selective crystallization of 2'-FL from an aqueous solution comprising 2'-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution.
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WO/2021/175878A1 |
The present invention provides a new type of galacto-oligosaccharide, having a mannose residue instead of a glucose residue at the reducing end. The invention also relates to compositions comprising this galacto-oligosaccharide, its prep...
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WO/2021/172955A1 |
The present invention provides an intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor using same. According to the present invention, by developing a compound of chemical formula 5 corr...
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WO/2021/169606A1 |
Disclosed in the present invention are an avermectin B2a ethylenic derivative, and a preparation method therefor and the use thereof. The structural formula of the avermectin B2a ethylenic derivative is as represented by formula I. The c...
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WO/2021/160701A1 |
The invention relates to a crystalline allulose with a defined particle size distribution, to a process for the production and use thereof. The new allulose quality is characterised by the fact that it improves the shelf life of end prod...
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WO/2021/160564A1 |
Proposed are allulose concentrates in solid amorphous form, which are characterised in that they contain at least approximately 20 wt. % allulose. Also proposed is a method for producing said concentrates.
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WO/2021/160670A1 |
The present invention relates to a 3'-ketoglycoside compound defined by formula (I) and its use for controlled release of alcohols, in particular alcohols showing an insect repellent effect. It relates also to a process for preparing the...
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WO/2021/158932A1 |
A glucose in solid form containing a matrix phase and a plurality of carbohydrate crystals within said matrix phase, the matrix phase containing amorphous glucose and water, wherein the carbohydrate crystals comprise glucose and optional...
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WO/2021/153770A1 |
The present invention provides an efficient process for preparing a nucleic acid oligomer, that is, a process for preparing a nucleic acid having a phosphate triester bond effectively by oxidizing a nucleic acid precursor having a phosph...
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WO/2021/155157A1 |
A process for recovery and purification of HMOs comprising: (a) providing an HMO-containing fermentation broth comprising biomass; (b) separating the fermentation broth to form a separated HMO-containing stream and a biomass waste stream...
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WO/2021/143194A1 |
The present invention relates to a catalyst for a phosgenation reaction and a phosgenation reaction method. The catalyst for a phosgenation reaction of the present invention is a phosphinyl ionic liquid as represented by general formula ...
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WO/2021/143812A1 |
The present invention relates to a method for preparing compound I, N-(β-L-rhamnopyranosyl)ferulamide, and the use of compound I in the preparation of a medicament for alleviating or treating mitochondrial dysfunction and Aβ-induced mi...
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WO/2021/142312A1 |
Novel compositions comprising heparinoid-related compounds, manufacturing and treatment methods, kits and dosage forms thereof, are provided.
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WO/2021/140471A1 |
A method of making nucleoside 1, which has a 3-hydrocarbyl-5-fluoro-5-(hydroxy-methyl)tetrahydrofuran-3,4
-diol ring system, where hydrocarbyl group R1 is lower alkyl, lower alkenyl, or lower alkynyl and R2 may be an adenine moiety havin...
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WO/2021/141979A1 |
Disclosed are C-glycoside amine derivatives of the formula: R-CH2-C(CH3)-NH-R2 wherein R is a saccharide (e.g., as described in U.S. Patent 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3-C(O)-R3 wherein R3 ...
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WO/2021/134408A1 |
The present invention relates to preparation, impurity removal and purification methods for glycyrrhizic acid monovalent salt. The preparation method for glycyrrhizic acid monovalent salt comprises mixing a glycyrrhizinate mixture and a ...
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WO/2021/135335A1 |
The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. More specifically, the present invention relates to a liver-targeting compound having thyroid hormone receptor agonist ch...
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WO/2021/134407A1 |
A method for extracting a crude product of glycyrrhizic acid and glycyrrhizic flavone from licorice and purifying to obtain glycyrrhizinate. In the method, a medicinal material of licorice and an organic solvent are mixed at a certain ra...
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WO/2021/129241A1 |
Provided is an application of a salidroside derivative in a skin-whitening agent for external use, belonging to the technical field of skincare products. The present invention can enhance the whitening activity of salidroside, and can ut...
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WO/2021/133148A1 |
The present invention provides a method for separating polysaccharides from a seaweed and polysaccharides obtained by the method, the method comprising: a pretreatment step of aging a seaweed at 20-50 °C and extracting same with a solve...
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WO/2021/122719A1 |
The present invention relates to a process for preparing a compound of formula (I), wherein said process is suitable for large scale synthesis.
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WO/2021/127642A1 |
Disclosed are methods of forming an epimer or a dehydrated isomer of a pyranose monosaccharide or a pyranose saccharide residue in an oligosaccharide or a glycoside.
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WO/2021/121270A1 |
A method for purifying an SGLTs inhibitor and an application thereof. The SGLTs inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)
methyl)-4- ethyl phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,
4-tri...
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WO/2021/122103A1 |
The present invention relates to a method for producing a human milk oligosaccharide (HMO) containing at least one HMO compound, characterized in that an aqueous solution containing the at least one HMO compound and at least one acid is ...
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WO/2021/124234A1 |
The present invention relates to the separation and isolation of sialylated human milk oligosaccharides (HMOs) from the reaction mixture in which they are produced.
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WO/2021/115380A1 |
Disclosed is a compound having a neuroprotective effect, a preparation method therefor and a use thereof. Specifically, the compound has the structure shown by formula A, the definition of each group and substituent being as described in...
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WO/2021/114200A1 |
A preparation method for sugar esters, wherein sucrose and hydrogenated palm oil undergo a transesterification reaction without the addition of a solvent to obtain a crude products of sugar esters. The preparation method does not use sol...
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WO/2021/119333A1 |
The present disclosure provides methods, compositions, and kits for the rapid release, labeling, and detection of O-glycans present on a glycoconjugate, such as a glycoprotein, glycopeptide, peptidoglycan, or proteoglycan of interest. Th...
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WO/2021/110773A1 |
The present invention provides apparatuses and methods for the synthesis of oligonucleotides and related compounds. In particular, the present invention allows to effectively prepare reagents to be fed into an apparatus for the synthesis...
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WO/2021/108291A1 |
The disclosure is directed to monomers and methods for synthesizing oligonucleotides comprising at least one nucleoside comprising a 3'-hydroxyl group.
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WO/2021/107235A1 |
The present invention relates to a method for extracting PDRN from adhesive diatoms, and more specifically relates to an optimal method for extracting PDRN, via bead beating, grinding and plasma processing, from diatoms taken in together...
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WO/2021/098847A1 |
A clindamycin phosphate purification method, comprising: dissolving surfactant trioctylmethylammonium chloride (TOMAC) in organic solvent ethyl acetate to make a reverse micelle extraction system; dissolving surfactant actyl-β-D-glucopy...
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WO/2021/101003A1 |
The present invention relates to a method for synthesis of gliflozin and provides a synthesis method comprising: a first step of reacting a stream containing an initial reactant and a lactone with a stream containing n-butyllithium to pr...
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WO/2021/098843A1 |
An abamectin extraction method, comprising: performing extraction on abamectin residues using a dynamic ultrasonic extraction method, and concentrating the obtained liquid extract into extractum; performing extractive desugarization on t...
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WO/2021/097619A1 |
A glucosamine sulfate chloride double salt and a preparation method therefor, said method comprising: (1) carrying out a dissolution reaction with glucosamine hydrochloride and a sulfate; (2) then carrying out an ion exchange reaction be...
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