Title:
【発明の名称】ファルネシルタンパク質トランスフェラーゼ阻害剤
Document Type and Number:
Japanese Patent JP2000507587
Kind Code:
A
Abstract:
The present invention is directed to substituted benzodiazepine compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Inventors:
Graham, Samuel El
Anthony, Neville Jei
Way, Ji Jong S
Anthony, Neville Jei
Way, Ji Jong S
Application Number:
JP53551397A
Publication Date:
June 20, 2000
Filing Date:
March 31, 1997
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/00; A61K31/55; A61K31/551; A61K31/5513; A61P13/00; A61P13/12; A61P27/00; A61P27/02; A61P31/00; A61P31/12; A61P35/00; A61P43/00; C07D243/24; C07D403/12; (IPC1-7): C07D243/24; A61K31/5513; A61P13/12; A61P27/02; A61P31/12; A61P35/00; A61P43/00; C07D403/12
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)