Title:
【発明の名称】バイオセンサ装置および方法
Document Type and Number:
Japanese Patent JP2000510233
Kind Code:
A
Abstract:
A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil-coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.
Inventors:
Rennox, Earl. Bruce
Hodges, Robert S.
Irvine, Randal Tea.
Bundle, david
Armstrong, Glenn
Kitob, Pavel
Railton, Craig
Hodges, Robert S.
Irvine, Randal Tea.
Bundle, david
Armstrong, Glenn
Kitob, Pavel
Railton, Craig
Application Number:
JP53842297A
Publication Date:
August 08, 2000
Filing Date:
April 25, 1997
Export Citation:
Assignee:
Pence, Incorporated
McGill University
McGill University
International Classes:
C12Q1/00; C12Q1/68; G01N27/327; G01N33/566; G01N27/414; G01N27/416; G01N33/543; C40B40/10; (IPC1-7): G01N27/414; G01N27/327; G01N27/416; G01N33/566
Attorney, Agent or Firm:
Shusaku Yamamoto