Title:
【発明の名称】置換ピリミジン誘導体および薬剤としてのそれらの使用
Document Type and Number:
Japanese Patent JP2000516602
Kind Code:
A
Abstract:
PCT No. PCT/GB97/02029 Sec. 371 Date Feb. 12, 1999 Sec. 102(e) Date Feb. 12, 1999 PCT Filed Jul. 25, 1997 PCT Pub. No. WO98/06705 PCT Pub. Date Feb. 19, 1998This invention concerns heterocyclic derivatives which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives capable of inhibiting cholesterol biosynthesis and hence in lowering cholesterol levels in blood plasma. The present invention also relates to methods of using such heterocyclic derivatives in diseases and medical conditions such as hypercholesterolemia and atherosclerosis.
Inventors:
Brown, George Robert
Nicholas John, Newcombe
Stowex, Elaine Sophie Elizabeth
Waterson, david
Nicholas John, Newcombe
Stowex, Elaine Sophie Elizabeth
Waterson, david
Application Number:
JP50946998A
Publication Date:
December 12, 2000
Filing Date:
July 25, 1997
Export Citation:
Assignee:
Zeneca Limited
International Classes:
A61K31/505; A61K31/506; A61P9/10; A61P43/00; C07D239/48; C07D401/04; C07D401/12; C07D401/14; C07D409/12; C07D409/14; C07D413/12; C07D239/42; C07D413/14; (IPC1-7): C07D239/42; A61K31/505; A61K31/506; A61P9/10; A61P43/00; C07D239/48; C07D401/12; C07D409/12; C07D409/14; C07D413/12
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)