Title:
【発明の名称】クロストリジウム・ジフィシル・トキシンAの精製方法及び単一特異性抗体
Document Type and Number:
Japanese Patent JP2001505525
Kind Code:
A
Abstract:
A method is provided for the purification of Clostridium difficile Toxin A comprising reacting impure Toxin A with immobilized mono-specific polyclonal antibodies. The polyclonal antibodies are coupled to a hydrazide group containing matrix such as hydrazide activated agarose gel. The immobilized antibody is specific for Toxin A and will greatly purify Toxin A from a Toxin A containing solution. Antibodies raised to Toxin A purified according to the method are of higher activity than antibodies produced from prior art purified Toxin A.
Inventors:
Deutsch, John W.
Application Number:
JP52932096A
Publication Date:
April 24, 2001
Filing Date:
December 08, 1995
Export Citation:
Assignee:
Lee Laboratories, Inc.
International Classes:
G01N33/53; C07K1/22; C07K14/33; C07K16/12; C12P21/02; (IPC1-7): C07K14/33; C07K1/22; C07K16/12; C12P21/02; G01N33/53
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)