Title:
【発明の名称】造骨細胞特異的分裂促進因子及び該化合物を含む薬剤
Document Type and Number:
Japanese Patent JP2001518511
Kind Code:
A
Abstract:
New and known lysophosphatidyl acids (I) are useful for treating bone metabolism disorders such as osteoporosis, and for healing bones and wounds. The use of lysophosphatidyl acids of formula (I) and their salts, esters, derivatives and enantiomers/racemates is claimed for treating bone metabolism disorders. R1 = 6-24C alkyl, alkenyl or alkynyl; n = 0-12; X = O or NH. (I) are new, provided that when X = O, then n is not 7, 9, 11, 13 or 15. The following compounds are also excepted: (all-cis-5,8,11,14)-eicosatetraenoic acid-2-hydroxy-3-phosphonooxypropyl ester, cis-9,cis-12-octadecadienoic acid-2-hydroxy-3-phosphonooxypropyl ester, (all-cis-9,12,15)-octadecatrienoic acid-2-hydroxy-3-phosphonooxypropyl ester or cis-9-octadecenoic acid-2-hydroxy-3-phosphonooxypropyl ester.
Inventors:
Esvine, Angelica
Cling, rotor
Cling, rotor
Application Number:
JP2000514652A
Publication Date:
October 16, 2001
Filing Date:
September 30, 1998
Export Citation:
Assignee:
Roche Diagnostics Gaem Behr
International Classes:
A61K31/66; A61K31/662; A61P3/14; A61P19/00; A61K31/661; A61P19/08; A61P19/10; C07F9/09; (IPC1-7): A61K31/662; A61P3/14; A61P19/00; C07F9/09
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)