Title:
【発明の名称】蛍光分光法におけるシグナル増強造影剤としての酢酸
Document Type and Number:
Japanese Patent JP2001520393
Kind Code:
A
Abstract:
A method for using acetic acid as a signal enhancing contrast agent during fluorescence spectroscopy of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of detecting tissue abnormality in a diagnostic tissue sample in a patient, comprising the steps of obtaining a first fluorescence intensity spectrum from the diagnostic tissue sample; thereafter, applying acetic acid to the diagnostic tissue sample in sufficient concentration to alter the response of such diagnostic tissue sample to electromagnetic radiation for at least an effective period of time; during the effective period of time, obtaining a second fluorescence intensity spectrum from the diagnostic tissue sample; determining a parameter indicative of a change between the first and second fluorescence emission intensity spectra; and analyzing the determined parameter to determine a probability that the diagnostic tissue sample is normal or abnormal.
Inventors:
Richard-Coatum, Rebecca
Agra Wal, Anant
Pitrice, Costis
Uthzinger, Urs
Bruckner, Carey
Mitchell, Michele, Foren
Agra Wal, Anant
Pitrice, Costis
Uthzinger, Urs
Bruckner, Carey
Mitchell, Michele, Foren
Application Number:
JP2000516708A
Publication Date:
October 30, 2001
Filing Date:
October 20, 1998
Export Citation:
Assignee:
Board of Regents, The University of Texas System
International Classes:
G01N21/64; A61B10/00; G01N1/30; G01N15/14; G01N21/78; G01N33/48; G01N33/52; (IPC1-7): G01N21/78; A61B10/00; G01N21/64; G01N33/48
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)