Title:
【発明の名称】腫瘍自己抗原に対する免疫誘導
Document Type and Number:
Japanese Patent JP2002506618
Kind Code:
A
Abstract:
This invention provides methods and compositions for breaking tolerance to a self-antigen, especially in the context of a tumor-associated antigen. In one embodiment, the method utilized altered tumor antigens or tumor antigens derived from heterologous species to break immunological tolerance and induce a cross-reactive immune response against the corresponding native or self-antigen.
Inventors:
Kaplan, Joan
Gregory, Richard Jay
Gregory, Richard Jay
Application Number:
JP2000536244A
Publication Date:
March 05, 2002
Filing Date:
March 19, 1999
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
A61K35/12; A61K38/00; A61K39/00; A61P35/00; A61P37/04; A61P43/00; C12N5/07; C12N5/0783; C12N5/0784; C12N5/09; C12N5/10; (IPC1-7): C12N5/06; A61K35/12; A61K38/00; A61K39/00; A61P35/00; A61P43/00; C12N5/10
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)