Title:
【発明の名称】セロトニン作動薬
Document Type and Number:
Japanese Patent JP2002513018
Kind Code:
A
Abstract:
The present invention provides compounds represented by general formula (1), wherein: R1 is selected from H, OH,OR3, F, C1, Br, or I; R2 in each occurrence is H or both together are =O; R3 and R4 are independently selected from H, C1 to C6 alkyl or (CH2)nAr, the alkyl and Ar groups being optionally substituted by from 1 to 3 groups selected from NO2, F, C1, Br, I, -OH, -OR3, C1-C6 alkyl, C1-C6 alkoxy, -CF3, -CN, -S-C1-C6 alkyl, or -NH2; n is selected from 0, 1 or 2; X is CH or CH2; R2 is H or taken together are =O; Ar is aryl or heteroaryl, both optionally substituted; or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing these compounds for the inhibition of serotonin uptake and the treatment of CNS disorders, including depression.
Inventors:
Michael gerrard kelly
Yang Hee Kang
Yang Hee Kang
Application Number:
JP2000545857A
Publication Date:
May 08, 2002
Filing Date:
April 28, 1999
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/4427; A61K31/454; A61K31/4545; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D401/06; C07D401/14; (IPC1-7): C07D401/14; A61K31/454; A61K31/4545; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D401/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)