Title:
【発明の名称】ヒトα1dアドレナリン受容体に特異的な化合物およびその使用
Document Type and Number:
Japanese Patent JP2002520408
Kind Code:
A
Abstract:
This invention is directed towards a method of inhibiting activation of a human alpha1d adrenergic receptor which comprises contacting the receptor with a compound so as to inhibit activation of the receptor, wherein the compound binds selectively to a human alpha1d adrenergic receptor. This invention provides for a compound which binds selectively to a human alpha1d adrenergic receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier. This invention further provides for a method of treating a subject afflicted with a disease which is susceptible to treatment by antagonism of the human alpha1d adrenergic receptor which comprises administering to the subject an amount of the above defined compounds effective to treat the disease.
Inventors:
Conquer, Michael
Wetzel, John M
Noble, Stewart
Gurucho ski, Charles
Craig, Douglas A
Wetzel, John M
Noble, Stewart
Gurucho ski, Charles
Craig, Douglas A
Application Number:
JP2000560118A
Publication Date:
July 09, 2002
Filing Date:
July 16, 1999
Export Citation:
Assignee:
Synaptic Pharmaceuticals Corporation
International Classes:
A61K31/00; A61K31/438; A61K31/4747; A61K31/495; A61K31/496; A61P9/12; A61P13/00; A61P43/00; C07D221/20; C07D295/06; C07D295/08; C07D401/06; (IPC1-7): C07D221/20; A61K31/438; A61K31/496; A61P9/12; A61P13/00; A61P43/00; C07D295/06; C07D295/08; C07D401/06
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)