Title:
【発明の名称】化学化合物
Document Type and Number:
Japanese Patent JP2002521376
Kind Code:
A
Abstract:
Compound of formula (I) wherein: A is a bicyclic heteroaryl, optionally substituted with one or more substituents; B is linker group connecting group A to group D and comprising a 3 or 4 atom linker where each atom is independently selected from carbon, oxygen, nitrogen and sulphur and is optionally subsituted with one or more C1-6 alkyl groups or two of such adjacent alkyl substituents may form a ring; C is aryl or a mono or bicyclic heteroaryl, each of which can be optionally substituted; D is an aryl or heteroaryl, both of which are optionally substituted R1 is hydrogen, C1-5 alkyl, C1-3 alkanoyl or C1-3 alkoxycarbonyl; R2 to R5 are each independently selected from hydrogen, C1-6 alkyl, aryl and heteroaryl containing up to 2 heteroatoms chosen from oxygen, sulphur and nitrogen, the aryl and heteroaryl optionally substituted with C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 alkanoyl, C1-6 alkylamino, C1-4alkylC1-6alkyoxyl, C1-6alkylaminoC1-6alkyl, nitro, cyano, halogeno, trifluoromethyl, hydroxy, (CH2)pOH where p is 1 or 2, -CO2Ra, and -CONRaRb, where Ra and Rb are independently selected from hydrogen and C1-6 alkyl or two of R2 to R5 can be taken together to form a 3 to 7 membered ring; R6 is an acidic functional group; r and s are each independently 0 or 1 with the proviso that r and s cannot both be 0; or a pharmaceutically acceptable salt or in vivo hydrolysable derivative thereof.
Inventors:
David Robert Britain
Craig John Stone
Gareth Morse Davis
Michael Stewart Large
Craig John Stone
Gareth Morse Davis
Michael Stewart Large
Application Number:
JP2000561180A
Publication Date:
July 16, 2002
Filing Date:
July 20, 1999
Export Citation:
Assignee:
AstraZeneca Actie Borak
International Classes:
A61K31/423; A61K31/428; A61K31/4427; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/14; A61P29/00; A61P37/06; A61P43/00; C07D263/58; C07D413/04; C07D277/82; C07D413/12; (IPC1-7): C07D263/58; A61K31/423; A61K31/428; A61K31/4427; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/14; A61P29/00; A61P37/06; C07D277/82; C07D413/12
Attorney, Agent or Firm:
Toshio Yano (3 outside)