Title:
【発明の名称】エールリチア・カニス(Ehrlichiacanis)の120kDaイムノドミナント抗原性タンパク質及び遺伝子
Document Type and Number:
Japanese Patent JP2002523087
Kind Code:
A
Abstract:
The present invention provides a 120-kDa protein gene of Ehrlichia canis, amplified by PCR using primers derived from the DNA sequences flanking the Ehrlichia chaffeensis 120-kDa protein gene. The recombinant E. canis 120-kDa protein contains 14 tandem repeat units with 36 amino acids each. The repeat units are hydrophilic and predicted to be surface-exposed. Also disclosed is that the recombinant E. canis 120-kDa protein is antigenic and reacts with sera from dogs convalescent from canine ehrlichiosis.
Inventors:
Walker, David, H.
You, Shree
You, Shree
Application Number:
JP2000567675A
Publication Date:
July 30, 2002
Filing Date:
August 27, 1999
Export Citation:
Assignee:
Research Development Foundation
International Classes:
C12N15/09; A61K38/00; A61K39/02; A61K48/00; A61P31/04; A61P37/04; C07K14/195; C07K14/29; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/31; C12N15/85; C12N15/86; C12P21/08; A61K39/00; C12R1/01; (IPC1-7): C12N15/09; A61K38/00; A61K39/02; A61K48/00; A61P31/04; A61P37/04; C07K14/29; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Foreign References:
| WO1997045540A1 | 1997-12-04 |
Attorney, Agent or Firm:
Morio Sada