Title:
【発明の名称】カドヘリン-11発現、アッセイおよび細胞浸潤性のための処置
Document Type and Number:
Japanese Patent JP2002528110
Kind Code:
A
Abstract:
A method of modulating differentiation or neoplastic transformation of cells is provided in which the cells are caused to increase or decrease cad-11 expression or function. Such method has application in affecting differentiation or neoplastic transformation of cells, preventing or terminating pregnancy by altering cad-11 function or expression in trophoblast cells, or for reducing the viability of carcinoma cells having a low to moderate metastatic potential. The use of agents which increase or decrease cad-11 expression or function is also provided, including such use for preparation of medicaments for modulating differentiation or neoplastic transformation of cells. A method for assessing the metastatic potential of carcinoma cells is also provided.
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Inventors:
Mackalman, Colin, Dee.
Application Number:
JP2000579623A
Publication Date:
September 03, 2002
Filing Date:
October 29, 1999
Export Citation:
Assignee:
THE UNIVERSITY OF BRITISH COLUMBIA
International Classes:
G01N33/50; A61K31/565; A61K31/57; A61K31/7088; A61K39/395; A61K45/00; A61P5/30; A61P5/34; A61P15/00; A61P15/04; A61P35/00; C07K14/705; C12N5/10; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): C12N15/09; A61K31/565; A61K31/57; A61K31/7088; A61K39/395; A61K45/00; A61P5/30; A61P5/34; A61P15/00; A61P15/04; A61P35/00; C12N5/10; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)