【発明の名称】免疫原性タンパク質の改変方法

Title:

【発明の名称】免疫原性タンパク質の改変方法

Document Type and Number:

Japanese Patent JP2002534959

Kind Code:

A

Abstract:

It is known that proteins, or parts of them, may be rendered non- or less immunogenic to humans or other species by identifying one or more potential T cell epitopes and eliminating them by amino acid modification. Conventionally, certain epitopes may be retained in a protein sequence if the peptides constituting such epitopes are present in endogenous human protein, since they would be recognised as "self". However, it has now been found that even self epitopes may give rise to immune reactions. The invention provides for their elimination, for example by recombinant DNA technology, to render them more useful for administration to humans, for example for therapeutic or diagnostic purposes.

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Inventors:

Car, francis, joseph
Adair, Fiona, Suzanne
Hamilton, Anita, Anne
Carter, graham

Application Number:

JP2000586759A

Publication Date:

October 22, 2002

Filing Date:

December 08, 1999

Export Citation:

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Assignee:

Biovation limited

International Classes:

G01N33/50; A61K38/00; C07K1/00; C07K14/315; C07K14/435; C07K14/47; C07K16/46; C12N9/48; C12N9/70; C12N15/09; C12P21/02; G01N33/15; G01N33/563; (IPC1-7): C12N15/09; A61K38/00; C07K1/00; C07K14/47; C12P21/02; G01N33/15; G01N33/50

Domestic Patent References:

JP7506810U

Foreign References:

WO1998052976A1	1998-11-26
WO1996029344A1	1996-09-26

Attorney, Agent or Firm:

Mikio Hatta (4 outside)

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