Title:
【発明の名称】METH1およびMETH2ポリヌクレオチドおよびポリペプチド
Document Type and Number:
Japanese Patent JP2003500041
Kind Code:
A
Abstract:
The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
Inventors:
Iruela-Arispe, Luisa
Hastings, Greg A.
Reuben, Stephen M.
Jonah, Tudenkael.
Trully, Stephen H.
Phonewald, James A.
Terret, Jonathan A.
Hastings, Greg A.
Reuben, Stephen M.
Jonah, Tudenkael.
Trully, Stephen H.
Phonewald, James A.
Terret, Jonathan A.
Application Number:
JP2000619832A
Publication Date:
January 07, 2003
Filing Date:
May 25, 2000
Export Citation:
Assignee:
Human Genome Sciences, Inc.
SMITHKLINE BEECHAM CORPORATION
Beth Israel Deacones Medical Center
Iruela-Arispe, Luisa
Hastings, Greg A.
Reuben, Stephen M.
Jonah, Tudenkael.
Trully, Stephen H.
Phonewald, James A.
Terret, Jonathan A.
SMITHKLINE BEECHAM CORPORATION
Beth Israel Deacones Medical Center
Iruela-Arispe, Luisa
Hastings, Greg A.
Reuben, Stephen M.
Jonah, Tudenkael.
Trully, Stephen H.
Phonewald, James A.
Terret, Jonathan A.
International Classes:
C12N15/09; A61K38/46; A61K48/00; A61P1/04; A61P9/00; A61P9/10; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P29/00; A61P35/00; C07K14/47; C07K14/78; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; A61K38/00; (IPC1-7): C12N15/09; A61K38/46; A61K48/00; A61P1/04; A61P9/00; A61P9/10; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P29/00; A61P35/00; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Shusaku Yamamoto