Title:
【発明の名称】インテグリン受容体アンタゴニスト
Document Type and Number:
Japanese Patent JP2003502373
Kind Code:
A
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
Inventors:
Mark Gun, Dagan
Hartman, Yogyi Day
Perkins, The Ames
Ile, Nathan
Hartman, Yogyi Day
Perkins, The Ames
Ile, Nathan
Application Number:
JP2001504380A
Publication Date:
January 21, 2003
Filing Date:
June 19, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/4375; A61K31/454; A61K31/496; A61K45/06; A61P9/10; A61P19/02; A61P19/08; A61P19/10; A61P27/06; A61P29/00; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07D401/12; C07D471/04; (IPC1-7): C07D401/12; A61K31/4375; A61K31/454; A61K31/496; A61P9/10; A61P19/02; A61P19/08; A61P19/10; A61P27/06; A61P29/00; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07D471/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)