Title:
【発明の名称】アリール置換されたピリジン、ピリミジン、ピラジン、およびトリアジンならびにそれらの使用
Document Type and Number:
Japanese Patent JP2003527376
Kind Code:
A
Abstract:
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I:or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Inventors:
Hogenkamp, Dark Jay.
Newen, Phone
Xiao, Bin
Newen, Phone
Xiao, Bin
Application Number:
JP2001567706A
Publication Date:
September 16, 2003
Filing Date:
March 12, 2001
Export Citation:
Assignee:
Euro-Celtic S.A.
International Classes:
A61K31/44; A61K31/4453; A61K31/496; A61K31/4965; A61K31/505; A61K31/506; A61K31/53; A61P9/06; A61P9/10; A61P23/02; A61P25/04; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P27/10; A61P29/02; C07D213/81; C07D239/00; C07D239/26; C07D239/28; C07D239/38; C07D241/24; C07D241/26; C07D251/24; C07D253/06; C07D295/12; C07D403/04; C07D413/04; C07D251/22; (IPC1-7): C07D213/81; A61K31/44; A61K31/4453; A61K31/496; A61K31/4965; A61K31/505; A61K31/506; A61K31/53; A61P9/06; A61P9/10; A61P23/02; A61P25/04; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P27/10; A61P29/02; C07D239/26; C07D239/28; C07D239/38; C07D241/24; C07D241/26; C07D251/22; C07D253/06; C07D295/12; C07D403/04; C07D413/04
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)