【発明の名称】ペプチドT投与による前期遺伝子発現変更に基づくウィルス性疾患その他の疾病治療法

Japanese Patent JP2003528817

A

A method for inhibiting viral replication and for treating neurotropic conditions by regulating/inhibiting immediate early gene expression in host cells comprises administrating an inhibiting/regulating effective amount of a peptide of formula (I): R-Ser-Thr-Thr-Thr-Asn-Tyr-R where R represents an amino terminal residue Ala- or D- Ala and R represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II): R1-R2-R3-R4-R5 where R1 is an amino terminal residue Thr-, Ser-, Asn-, Glu-, Arg-, Ile- or Leu-, R2 is Thr, Ser, or Asp, R3 is Thr, Ser, Asn, Arg, Gln, Lys, or Trp, R4 is Tyr and R5 is preferably a carboxy terminal residue -Thr, -Arg or Gly or a derivative thereof with a corresponding D-amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals, in a physiologically suitable carrier.