Title:
【発明の名称】インドル-3-イル誘導体
Document Type and Number:
Japanese Patent JP2003530319
Kind Code:
A
Abstract:
Indol-3-yl derivatives of the general formula I in which A, B, X, R1, R2, R3, R4, R5, n and m are as defined in Patent claim 1, and their physiologically acceptable salts or solvates are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammations, tumours, osteoporosis, rheumatic arthritis, macular degenerative disease, diabetic retinopathy, infections and restenosis after angioplasty or in pathological processes maintained or propagated by angiogenesis.
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Inventors:
Godman, Zimon
Gottschrich, Rudolf
Wiesner, Machias
Gottschrich, Rudolf
Wiesner, Machias
Application Number:
JP2001558443A
Publication Date:
October 14, 2003
Filing Date:
January 05, 2001
Export Citation:
Assignee:
Merck Patent Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/404; A61K31/405; A61K31/4178; A61K31/4184; A61K31/4439; A61K31/506; A61P7/02; A61P9/00; A61P9/10; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07D209/18; C07D209/20; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D409/06; C07D417/06; C07D417/14; C07D401/06; (IPC1-7): C07D209/18; A61K31/405; A61K31/4178; A61K31/4184; A61K31/4439; A61K31/506; A61P7/02; A61P9/00; A61P9/10; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07D209/20; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D409/06; C07D417/06; C07D417/14
Domestic Patent References:
| JP4425699B2 | 2010-03-03 | |||
| JPH03115263A | 1991-05-16 |
Foreign References:
| EP0498268A2 | 1992-08-12 | |||
| US4824850A | 1989-04-25 | |||
| WO1999051576A1 | 1999-10-14 | |||
| WO1999051575A1 | 1999-10-14 | |||
| WO1998008817A1 | 1998-03-05 | |||
| WO1999043654A2 | 1999-09-02 |
Attorney, Agent or Firm:
Nobuyuki Kaneda (2 others)