Title:
【発明の名称】N-[4-[2-(2-アミノ-4,7-ジヒドロ-4-オキソ-3H-ピロロ[2,3-d]ピリミジン-5-イル)エチル]ベンゾイル]-L-グルタミン酸の新規結晶形およびその製造方法
Document Type and Number:
Japanese Patent JP2003530321
Kind Code:
A
Abstract:
The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid.
Inventors:
Eric Christopher Celius
Susan Marie Luzer-Edens
Sharon van den berghe snowlek
Susan Marie Luzer-Edens
Sharon van den berghe snowlek
Application Number:
JP2001562542A
Publication Date:
October 14, 2003
Filing Date:
February 12, 2001
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
A61K9/08; A61K31/519; A61P35/00; C07D487/04; (IPC1-7): C07D487/04; A61K9/08; A61K31/519; A61P35/00
Foreign References:
| WO1999016742A1 | 1999-04-08 | |||
| EP0905128A1 | 1999-03-31 | |||
| US6013828A | 2000-01-11 | |||
| WO1999016742A1 | 1999-04-08 | |||
| EP0905128A1 | 1999-03-31 | |||
| US6013828A | 2000-01-11 |
Other References:
JPN6010069643, Ｂａｒｎｅｔｔ，Ｃ．Ｊ．，ｅｔ ａｌ, Ｏｒｇａｎｉｃ Ｐｒｏｃｅｓｓ Ｒｅｓｅａｒｃｈ ＆ Ｄｅｖｅｌｏｐｍｅｎｔ, 1999, Ｖｏｌ．３， Ｎｏ．３, ｐｐ １８４−１８８
Attorney, Agent or Firm:
Kaoru Aoyama (3 people outside)