Title:
【発明の名称】ABC1遺伝子の調節核酸配列
Document Type and Number:
Japanese Patent JP2003531613
Kind Code:
A
Abstract:
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.
Inventors:
Rozier-Monteuux, Marie-Francoise
Prado, Catherine
Lemoanne, Sandrinnes
Nolan, Loran
Downeful, Patrice
Brewer,bryan
Doubergeier, Nicola
Remary, Alan
Santa Marina-Fuozillo, Sylvia
Prado, Catherine
Lemoanne, Sandrinnes
Nolan, Loran
Downeful, Patrice
Brewer,bryan
Doubergeier, Nicola
Remary, Alan
Santa Marina-Fuozillo, Sylvia
Application Number:
JP2001580353A
Publication Date:
October 28, 2003
Filing Date:
May 02, 2001
Export Citation:
Assignee:
Avantes Furuma S.A.
International Classes:
A01K67/027; A61K45/00; A61P3/06; A61P9/10; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12Q1/68; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K45/00; A61P3/06; A61P9/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/68
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)