Title:
VEGF調節遺伝子及びそれらを利用する方法
Document Type and Number:
Japanese Patent JP2004501608
Kind Code:
A
Abstract:
The present invention provides methods for modulating angiogenesis and/or apoptosis comprising modulating the activity of at least one VEGF-modulated gene polypeptide. The invention also provides pharmaceutical compositions for modulating angiogenesis and apoptosis for the prevention or treatment of diseases associated with VEGF-modulated genes expression. The invention also provides diagnostic assays that use VEGF-modulated gene polynucleotides that hybridize with naturally occurring sequences encoding VEGF-modulated genes and antibodies that specifically bind to the protein. The invention also provides novel human and mouse arginine-rich proteins (ARPs) and nucleotide sequences. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding ARPs and for a method for producing the protein.
Inventors:
Lastelli, Luca, Kay.
Gerber, Hans-Peter
Gerber, Hans-Peter
Application Number:
JP2001568372A
Publication Date:
January 22, 2004
Filing Date:
March 21, 2001
Export Citation:
Assignee:
Quragen Corporation
International Classes:
A01K67/027; A61K39/395; A61K45/00; A61P9/00; A61P9/10; A61P35/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12Q1/02; C12Q1/48; C12Q1/68; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K39/395; A61K45/00; A61P9/00; A61P9/10; A61P35/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; C12Q1/48; C12Q1/68
Other References:
JPN6010075535, Ｂｒ． Ｊ． Ｐｈａｒｍａｃｏｌ．, 1999, ｖｏｌ．１２７， ｎｏ．２, ｐｐ．５３７−５４５
JPN6010075537, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1998, ｖｏｌ．２７３， ｎｏ．８, ｐｐ．４４００−４４０５
JPN6010075537, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1998, ｖｏｌ．２７３， ｎｏ．８, ｐｐ．４４００−４４０５
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori