Title:
ペプチド選択方法
Document Type and Number:
Japanese Patent JP2004506921
Kind Code:
A
Abstract:
There is provided a tolerogenic human peptide, capable of binding to an MHC class I or II molecule without further antigen processing, for use in the treatment and/or prevention of multiple sclerosis, which peptide is selected from the following myelin basic protein (MBP) peptides: 83-99 and 131- 145.
Inventors:
Wraith, David, Cameron
Anderton, Stefan, Mark
Mazza, Graziella
Ponsford, Mary
Streeter, Heather, Barbara
Anderton, Stefan, Mark
Mazza, Graziella
Ponsford, Mary
Streeter, Heather, Barbara
Application Number:
JP2002521505A
Publication Date:
March 04, 2004
Filing Date:
August 17, 2001
Export Citation:
Assignee:
Apitope Technology (Bristol) Limited
International Classes:
A61K38/00; A61P37/06; A61P37/08; C07K14/46; C07K14/47; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/566; A61K39/00; C07K; (IPC1-7): G01N33/50; A61K38/00; A61P37/06; A61P37/08; C07K14/46; C12Q1/02; G01N33/15; G01N33/53; G01N33/566
Domestic Patent References:
| JPH10500109A | 1998-01-06 | |||
| JPH05507911A | 1993-11-11 | |||
| JPH10509172A | 1998-09-08 | |||
| JPH06507168A | 1994-08-11 | |||
| JPH10500109A | 1998-01-06 | |||
| JPH10509172A | 1998-09-08 | |||
| JPH06507168A | 1994-08-11 | |||
| JPH05507911A | 1993-11-11 |
Foreign References:
| WO1997041440A1 | 1997-11-06 | |||
| WO2000011027A1 | 2000-03-02 | |||
| WO1997041440A1 | 1997-11-06 | |||
| WO2000011027A1 | 2000-03-02 |
Other References:
JPN6011037416; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ａｎ ａｕｔｏａｎｔｉｇｅｎｉｃ Ｔ ｃｅｌｌ ｅｐｉｔｏｐｅ ｆｏｒｍｓ ｕｎｓｔａｂｌｅ ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ ｃｌａｓｓ ＩＩ ＭＨＣ： ａ ｎｏｖｅｌ ｒｏｕｔｅ ｆｏｒ ｅｓｃａｐｅ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ５， ｎｏ． ９, 1993, １１５１-１１５８
JPN6011037418; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ｔｈｅ ｎａｔｕｒｅ ｏｆ ｃｒｙｐｔｉｃ ｅｐｉｔｏｐｅｓ ｗｉｔｈｉｎ ｔｈｅ ｓｅｌｆ-ａｎｔｉｇｅｎ ｍｙｅｌｉｎ ｂａｓｉｃ ｐｒｏｔｅｉｎ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ８， Ｎｏ． ７, 1996, １０３５-１０４３
JPN6011037416; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ａｎ ａｕｔｏａｎｔｉｇｅｎｉｃ Ｔ ｃｅｌｌ ｅｐｉｔｏｐｅ ｆｏｒｍｓ ｕｎｓｔａｂｌｅ ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ ｃｌａｓｓ ＩＩ ＭＨＣ： ａ ｎｏｖｅｌ ｒｏｕｔｅ ｆｏｒ ｅｓｃａｐｅ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ５， ｎｏ． ９, 1993, １１５１-１１５８
JPN6011037418; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ｔｈｅ ｎａｔｕｒｅ ｏｆ ｃｒｙｐｔｉｃ ｅｐｉｔｏｐｅｓ ｗｉｔｈｉｎ ｔｈｅ ｓｅｌｆ-ａｎｔｉｇｅｎ ｍｙｅｌｉｎ ｂａｓｉｃ ｐｒｏｔｅｉｎ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ８， Ｎｏ． ７, 1996, １０３５-１０４３
JPN6011037418; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ｔｈｅ ｎａｔｕｒｅ ｏｆ ｃｒｙｐｔｉｃ ｅｐｉｔｏｐｅｓ ｗｉｔｈｉｎ ｔｈｅ ｓｅｌｆ-ａｎｔｉｇｅｎ ｍｙｅｌｉｎ ｂａｓｉｃ ｐｒｏｔｅｉｎ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ８， Ｎｏ． ７, 1996, １０３５-１０４３
JPN6011037416; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ａｎ ａｕｔｏａｎｔｉｇｅｎｉｃ Ｔ ｃｅｌｌ ｅｐｉｔｏｐｅ ｆｏｒｍｓ ｕｎｓｔａｂｌｅ ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ ｃｌａｓｓ ＩＩ ＭＨＣ： ａ ｎｏｖｅｌ ｒｏｕｔｅ ｆｏｒ ｅｓｃａｐｅ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ５， ｎｏ． ９, 1993, １１５１-１１５８
JPN6011037418; Ｐａｕｌ Ｊ． Ｆａｉｒｃｈｉｌｄ， ｅｔ ａｌ．: 'Ｔｈｅ ｎａｔｕｒｅ ｏｆ ｃｒｙｐｔｉｃ ｅｐｉｔｏｐｅｓ ｗｉｔｈｉｎ ｔｈｅ ｓｅｌｆ-ａｎｔｉｇｅｎ ｍｙｅｌｉｎ ｂａｓｉｃ ｐｒｏｔｅｉｎ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． ８， Ｎｏ． ７, 1996, １０３５-１０４３
Attorney, Agent or Firm:
Akira Koike
Eiichi Tamura
Seiji Iga
Eiichi Tamura
Seiji Iga