Title:
α-1A/Bアドレナリン作動性受容体拮抗薬としてのキナゾロン誘導体
Document Type and Number:
Japanese Patent JP2004519454
Kind Code:
A
Abstract:
This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by formula (I) wherein Z is -C(O)- or -S(O)2-, X is carbon or nitrogen, Y is carbon, and X-Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatise ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring; chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their preparation and their use as therapeutic agents.
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Inventors:
Becker, Cyrus Kefra
Caloon, John Marie
Melville, Chris Richard
Padilla, Fernando
Pfister, Jörg Roland
Tsang, Xiao Ming
Caloon, John Marie
Melville, Chris Richard
Padilla, Fernando
Pfister, Jörg Roland
Tsang, Xiao Ming
Application Number:
JP2002554677A
Publication Date:
July 02, 2004
Filing Date:
December 17, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/517; A61K31/5377; A61K31/549; A61P13/02; A61P13/08; A61P15/08; A61P25/04; A61P29/00; A61P43/00; C07D401/02; C07D401/04; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D417/02; C07D417/04; C07D417/14; C07D471/04; C07D471/14; C07D487/04; C07D491/04; A61K; A61P; C07D; (IPC1-7): C07D401/02; A61K31/517; A61K31/5377; A61K31/549; A61P13/02; A61P15/08; A61P25/04; A61P29/00; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D417/02; C07D471/04; C07D487/04
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda