Title:
レオウイルス由来の膜融合タンパク質
Document Type and Number:
Japanese Patent JP2004520019
Kind Code:
A
Abstract:
In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
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Inventors:
Roy, Duncan
Application Number:
JP2002546575A
Publication Date:
July 08, 2004
Filing Date:
November 30, 2001
Export Citation:
Assignee:
FUSOGENIX INC.
International Classes:
A61K9/127; C07K14/14; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/09; C12N15/46; (IPC1-7): C12N15/09; A61K9/127; C07K14/14; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota