抗コリン作用剤チオトロピウム臭化物の製造方法 - Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft

Title:

抗コリン作用剤チオトロピウム臭化物の製造方法

Document Type and Number:

Japanese Patent JP2004525099

Kind Code:

A

Abstract:

Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide.

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Inventors:

Van holzer rolf
Graurich manfred
Rutke Sufen
Mates andreas
Meissner Helmut
Specht Peter
Brader Wolfgang

Application Number:

JP2002552935A

Publication Date:

August 19, 2004

Filing Date:

December 12, 2001

Export Citation:

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Assignee:

Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft

International Classes:

A61K31/46; A61P11/06; A61P11/08; A61P25/00; A61P43/00; C07D451/06; C07D451/10; (IPC1-7): C07D451/10; C07D451/06

Attorney, Agent or Firm:

Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda

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