Title:
マクロファージ遊走阻止因子レセプターとしてのMHCクラスII不変鎖ポリペプチド使用のための方法及び組成物
Document Type and Number:
Japanese Patent JP2004532839
Kind Code:
A
Abstract:
Methods and compositions for using the MEW class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
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Inventors:
Bucara, Richard Jay
Donnelly, schemus
Ren, Lynn
Mets, Christine N
Robert Mitchell
Donnelly, schemus
Ren, Lynn
Mets, Christine N
Robert Mitchell
Application Number:
JP2002577925A
Publication Date:
October 28, 2004
Filing Date:
March 29, 2002
Export Citation:
Assignee:
CYTOKINE PHARMASCIENCES,INC.
International Classes:
A61K31/7084; A61K39/395; A61K45/00; A61K48/00; A61P19/02; A61P29/00; A61P31/04; A61P31/10; A61P33/00; A61P35/00; C07K14/47; C07K16/18; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/68; (IPC1-7): C07K14/47; A61K31/7084; A61K45/00; A61K48/00; A61P19/02; A61P29/00; A61P31/04; A61P31/10; A61P33/00; A61P35/00; C07K16/18; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda