Title:
ヒト以外の動物におけるヒト肝芽腫細胞の増殖
Document Type and Number:
Japanese Patent JP2004538012
Kind Code:
A
Abstract:
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin. The present invention further relates to the use of such animals as models of various liver diseases, including viral invention. Such embodiments are based on the discovery that transplanted human hepatocytes in chimeric livers were found to be susceptible to Hepatitis B virus and Hepatitis C virus infection.
Inventors:
Wu, George, Wye.
Woo, Catherine, H.
Woo, Catherine, H.
Application Number:
JP2003520277A
Publication Date:
December 24, 2004
Filing Date:
August 15, 2002
Export Citation:
Assignee:
UNIVERSITY OF CONNECTICUT
International Classes:
A01K67/027; A61K35/407; A61K39/00; A61K48/00; A61P1/16; C07K14/705; C12N5/071; C12N9/12; C12N9/72; C12N15/09; C12N15/113; C12Q1/68; C12Q1/70; G01N33/15; G01N33/50; A61K35/12; (IPC1-7): A01K67/027; C07K14/705; C12N15/09; C12Q1/70; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai