Title:
大環状金属錯体及び生体分子との結合体の製造のためのその使用
Document Type and Number:
Japanese Patent JP2005504745
Kind Code:
A
Abstract:
The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
Inventors:
Johannes Pratsek
Helibert Schmid-Willich
Gunter Mihil
Thomas Frenzel
Detlef Zurzure
Hans Bauer
Bernd Laduchel
Hans-Joachim Weinmann
Highco Schirmer
Helibert Schmid-Willich
Gunter Mihil
Thomas Frenzel
Detlef Zurzure
Hans Bauer
Bernd Laduchel
Hans-Joachim Weinmann
Highco Schirmer
Application Number:
JP2003515266A
Publication Date:
February 17, 2005
Filing Date:
July 18, 2002
Export Citation:
Assignee:
Schering Aktiengesellschaft
International Classes:
C07D403/04; A61K47/48; A61K49/00; A61K49/08; A61K49/14; A61K51/00; C07D257/02; C07F5/00; C07F9/38; (IPC1-7): C07D257/02; A61K49/00; A61K51/00; C07D403/04; C07F9/38
Domestic Patent References:
| JPH0656802A | 1994-03-01 | |||
| JPH04504247A | 1992-07-30 | |||
| JPH1121279A | 1999-01-26 | |||
| JPH07224050A | 1995-08-22 | |||
| JPH11510834A | 1999-09-21 | |||
| JPH09500660A | 1997-01-21 | |||
| JP2001504813A | 2001-04-10 |
Foreign References:
| WO1999005145A1 | 1999-02-04 | |||
| WO1999005128A1 | 1999-02-04 |
Other References:
J.AM.CHEM.SOC., vol. 122, JPN6009009796, 2000, pages 9781 - 9792, ISSN: 0001264145
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel