Title:
ケト酸の製造
Document Type and Number:
Japanese Patent JP2005507416
Kind Code:
A
Abstract:
An improved method of producing keto acids having the formula (I), wherein R1 and R2 independently represent (a) hydrogen, wherein at least one of R1 and R2 do not stand for hydrogen, (b) branched or unbranched alkyl of 1-18 carbon atoms, which may be substituted by C1-C4alkoxy or 2- or 3-tetrahydrofuryl, (c) a cycloalkyl of 4-8 carbon atoms, (d) C4-C8cycloalkyl-C1-C4alkyl, or phenyl, wherein both, cycloalkyl and phenyl, may be substituted by at least one member selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, (e) an aralkyl of 7-10 carbon atoms, or (f) R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, by reacting a m-amino phenol having the formula (II) with phthalic anhydride at an elevated temperature in the absence of an organic solvent, which comprises: (I) mixing m-amino phenol II and phthalic anhydride in a molar ratio of from 0.5 to 10:1, (II) melting the mixture of step I at an elevated temperature, (III) choosing a reaction time in the range of from 5 minutes to 40 hours, (IV) then separating the liquid phase from the solid phase as well as a method in which a solvent is added after the reaction.
Inventors:
Campbell, Jonathan
Henshall, John Barry
Taylor, James Philip
John Whitworth
Henshall, John Barry
Taylor, James Philip
John Whitworth
Application Number:
JP2003540129A
Publication Date:
March 17, 2005
Filing Date:
October 17, 2002
Export Citation:
Assignee:
Ciba Specialty Chemicals Holding Inc.
International Classes:
B41M5/30; B41M5/327; C07C221/00; C07C225/22; C07C227/02; C07C227/16; C07C229/52; C07C229/66; (IPC1-7): C07C221/00; C07C225/22
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Koshiro Tsukuda
Fumio Shinoda
Koshiro Tsukuda