Title:
治療的に有用なトリエチレングリコールコレステリルオリゴヌクレオチド
Document Type and Number:
Japanese Patent JP2005509607
Kind Code:
A
Abstract:
The present invention provides a composition comprising a 5'-OH, 3'-TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. The present invention provides methods of using this composition for induction of response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells or synovial cells, and methods of using this composition for treating disease.
Inventors:
Herrera-Gayor, Andrea Christina
Philips, Niger See.
Fillion, Mario Sea.
Philips, Niger See.
Fillion, Mario Sea.
Application Number:
JP2003532094A
Publication Date:
April 14, 2005
Filing Date:
October 03, 2002
Export Citation:
Assignee:
Bionike Life Sciences, Inc.
International Classes:
A61K45/00; A61K47/48; A61P19/02; A61P35/00; A61P35/02; A61P43/00; C07H21/00; C12N15/117; (IPC1-7): A61K47/48; A61K45/00; A61P19/02; A61P35/00; A61P35/02; A61P43/00
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama