Title:
MMP-2内の配列に基づいた化合物を使用する、血管形成および腫瘍増殖を阻害するための新規方法並びに組成物
Document Type and Number:
Japanese Patent JP2005517628
Kind Code:
A
Abstract:
The present invention provides methods and compositions for inhibiting angiogenesis, tumor growth and treating disease states using a peptide that contains a specific amino acid sequence of matrix metalloproteinase 2 (MMP-2). In one embodiment, the invention provides a peptide, which comprises the amino acid sequence Ile-Phe-Ala-Gly-Asp-Lys-Phe-Trp-Arg, preferably flanked by cysteine residues at the amino and carboxy termini. Additionally, the invention provides compositions for inhibiting angiogenesis or tumor growth or for treating disease states comprising organic and non-peptidic mimetics based on the above amino acid sequence as well as optimized sequences flanking the region of MMP-2 within which the sequence lies. Also provided are methods for detecting angiogenesis, tumorous tissue, metastases, and tumor invasion into a tissue by contacting a composition of the invention with a tissue and methods for screening compositions of the invention.
Inventors:
Brooks Petersea
Rodriguez Dorothy
Rodriguez Dorothy
Application Number:
JP2003501393A
Publication Date:
June 16, 2005
Filing Date:
May 31, 2002
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
G01N33/53; A61K31/7088; A61K38/00; A61K48/00; A61P9/00; A61P9/10; A61P17/06; A61P25/00; A61P29/00; A61P35/00; A61P35/04; C07K7/06; C12N9/64; C12Q1/37; G01N33/566; (IPC1-7): C07K7/06; A61K31/7088; A61K38/00; A61K48/00; A61P9/00; A61P9/10; A61P17/06; A61P25/00; A61P29/00; A61P35/00; A61P35/04; G01N33/53; G01N33/566
Domestic Patent References:
| JP2000516201A | 2000-12-05 |
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto