Title:
混合物中のリガンドおよび標的を検出する方法
Document Type and Number:
Japanese Patent JP2005522712
Kind Code:
A
Abstract:
The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, an amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to alpha1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa8-Xaa8-Xaa1-His-Xaa1-Xaa3, and amino acid sequence His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2, or an amino acid sequence selected from specific amino acid sequences provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa4-Xaa5-Xaa5, an amino acid sequence Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.
Inventors:
Hammond, David, Jay.
Lathrop, Julia, Tate
Lathrop, Julia, Tate
Application Number:
JP2003586604A
Publication Date:
July 28, 2005
Filing Date:
April 14, 2003
Export Citation:
Assignee:
American national red cross
International Classes:
G01N33/543; C07K1/04; C07K1/14; C07K5/087; C07K5/09; C07K5/097; C07K5/103; C07K7/04; C07K7/06; C12Q1/68; C12Q1/70; G01N33/53; G01N33/537; G01N33/554; G01N33/567; G01N33/569; (IPC1-7): G01N33/543
Domestic Patent References:
| JPS62110745A | 1987-05-21 | |||
| JPS61292062A | 1986-12-22 |
Foreign References:
| WO2001098765A1 | 2001-12-27 | |||
| WO2001069258A1 | 2001-09-20 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita