Title:
液体の有効成分の製剤を含んでなりかつ膨張可能な浸透圧組成物によりその放出を制御する経口の投薬形態
Document Type and Number:
Japanese Patent JP2005533084
Kind Code:
A
Abstract:
The present invention provides a controlled release oral dosage form for the delivery of a liquid active agent formulation. The dosage form of the present invention includes a reservoir formed of a water impermeable material and filled with a liquid active agent formulation. The dosage form of the present invention also includes an expandable osmotic composition positioned within the reservoir, and, optionally, the expandable osmotic composition is separated from contact with the liquid active agent formulation by a barrier layer that is substantially impermeable to the passage of liquid. To facilitate expulsion of the liquid active agent formulation, the dosage form of the present invention also includes an exit orifice. The material make-up and design of the reservoir included in the dosage form of the present invention allow the manufacture of an oral dosage form capable of more consistently achieving a desired release rate or release rate profile of active agent from a liquid formulation.
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Inventors:
Dong, Liang-Chiang
Shyahui, Kell
Alicia, Yam
Wong, Patrick S. L
Shyahui, Kell
Alicia, Yam
Wong, Patrick S. L
Application Number:
JP2004518034A
Publication Date:
November 04, 2005
Filing Date:
June 27, 2003
Export Citation:
Assignee:
Alza Corporation
International Classes:
A61K9/00; A61K9/52; A61K31/167; A61K31/57; A61K47/32; A61K47/34; A61J3/07; A61K47/38; A61K47/42; (IPC1-7): A61K9/52; A61J3/07; A61K47/32; A61K47/34; A61K47/38; A61K47/42
Attorney, Agent or Firm:
Heikichi Odashima