Title:
カチオンキャリヤー系において診断化合物および治療化合物を安定化させる新規方法
Document Type and Number:
Japanese Patent JP2005534718
Kind Code:
A
Abstract:
The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
Inventors:
Heinrich Haas
Thomas fichert
Brita Schulze
Tralf Peyman
Uwe Michaelis
Michael Taifel
Thomas fichert
Brita Schulze
Tralf Peyman
Uwe Michaelis
Michael Taifel
Application Number:
JP2004548889A
Publication Date:
November 17, 2005
Filing Date:
June 26, 2003
Export Citation:
Assignee:
Medigene Oncologie Gezel Shaft Mitt Beschlenktel Haftung
International Classes:
A61K9/127; A61K31/00; A61K31/335; A61K31/337; A61K31/47; A61K31/4745; A61K47/24; A61K47/28; A61K47/34; A61K47/48; A61K49/00; A61K49/18; A61K51/12; A61P9/00; A61P11/06; A61P17/02; A61K47/18; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P43/00; (IPC1-7): A61K47/18; A61K9/127; A61K31/337; A61K31/4745; A61K47/24; A61K47/28; A61K49/00; A61P9/00; A61P11/06; A61P17/02; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JPH09504517A | 1997-05-06 |
Foreign References:
| WO2001082899A2 | 2001-11-08 | |||
| WO2001017508A1 | 2001-03-15 | |||
| WO1999013816A2 | 1999-03-25 |
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard