CGRP拮抗剤BIBN4096の塩を含有する吸入粉末の調製方法 - Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft

Title:

CGRP拮抗剤BIBN4096の塩を含有する吸入粉末の調製方法

Document Type and Number:

Japanese Patent JP2005538934

Kind Code:

A

Abstract:

Acid addition salts (A) of the active agent base 1-(N2-(3,5-dibromo-N-((4-(3,4-dihydro-2(1H)-oxo-quinazolin-3-yl)-1-piperidinyl)-carbonyl)-D-tyrosyl)-L-lysyl)-4-(4-pyridinyl)-piperazine (BIBN4096) (I) are new. Acid addition salts (A) of the active agent base 1-(N2-(3,5-dibromo-N-((4-(3,4-dihydro-2(1H)-oxo-quinazolin-3-yl)-1-piperidinyl)-carbonyl)-D-tyrosyl)-L-lysyl)-4-(4-pyridinyl)-piperazine (BIBN4096) of formula (I) are new. Independent claims are also included for: (1) Preparation of (A); (2) Production of (A) in the form of an inhalable powder; and (3) An inhalable powder comprising (A) in the form of spherical nano-structured particles, where the particles have a specific surface of 1-20 (preferably 1-10) m2/g, a characteristic value Q(5.8) of 50-100% and a parameter X50 of 1-6 microm.

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Inventors:

Tork Michael
Veiler Claudias

Application Number:

JP2003569660A

Publication Date:

December 22, 2005

Filing Date:

February 14, 2003

Export Citation:

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Assignee:

Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft

International Classes:

A61K9/14; A61K9/72; A61K38/00; A61P25/06; C07D401/14; C07K1/113; C07K5/06; C07K5/065; (IPC1-7): C07K5/065; A61K9/14; A61K9/72; A61K38/00; A61P25/06; C07K1/113

Attorney, Agent or Firm:

Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama

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