Title:
癌治療用のSHHシグナル伝達経路阻害剤およびテストステロン抑制剤
Document Type and Number:
Japanese Patent JP2006503055
Kind Code:
A
Abstract:
A method of protecting a patient from possible adverse effects of a treatment involving inhibition of the SHH-signalling pathway in the patient, the method comprising suppressing testosterone or its effect in the patient. A method of treating a proliferative disease such as cancer in a patient the method comprising inhibiting the SHH-signalling pathway and suppressing testosterone or its effect in the patient. Typically, the SHH-signalling pathway is inhibited using cyclopamine or a derivative thereof, and testosterone is suppressed using any one or more of a GnRH antagonist, a GnRH agonist, an androgen antagonist or a Sa-reductase inhibitor.
Inventors:
Thomson, Axel, Andreas
Application Number:
JP2004537316A
Publication Date:
January 26, 2006
Filing Date:
September 17, 2003
Export Citation:
Assignee:
Medical Research Council
International Classes:
A61K45/06; A61K31/435; A61K31/4741; A61K31/4985; A61K31/517; A61K31/58; A61P1/04; A61P3/02; A61P3/06; A61P5/28; A61P9/00; A61P9/10; A61P9/14; A61P13/08; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/10; A61P31/22; A61P33/02; A61P35/00; A61P35/04; A61P39/00; A61P43/00
Foreign References:
| WO2002030462A2 | 2002-04-18 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori