Title:
ジペプチジルペプチダーゼ-IV(DPP-IV)阻害薬としての医薬組成物
Document Type and Number:
Japanese Patent JP2006503057
Kind Code:
A
Abstract:
The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R<1>,R<2> and R<3> have the definitions given in the description.
Inventors:
Madder, David
Pay, Chiyonhua
Daisy
Deeuritsk, Staban Davryu
Weedman, Paul Yee
Yong, Hong
Fernstra, Melitsa Jei
Kopetsuka, Hana
Li, Sheaofen
Long Netker, Kenton
Siam, Hin El
Stewart, Kent Day
Syutie Pankievich, Bruce Gee
Pay, Chiyonhua
Daisy
Deeuritsk, Staban Davryu
Weedman, Paul Yee
Yong, Hong
Fernstra, Melitsa Jei
Kopetsuka, Hana
Li, Sheaofen
Long Netker, Kenton
Siam, Hin El
Stewart, Kent Day
Syutie Pankievich, Bruce Gee
Application Number:
JP2004537831A
Publication Date:
January 26, 2006
Filing Date:
September 15, 2003
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D207/16; A61K31/40; A61K31/4025; A61K31/428; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/506; A61P3/04; A61P3/10; A61P5/48; A61P37/02; A61P43/00; C07D207/27; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D417/12; C07D207/26
Foreign References:
| WO2001096295A2 | 2001-12-20 | |||
| US6172081B1 | 2001-01-09 | |||
| WO2000034241A1 | 2000-06-15 | |||
| WO2001096295A2 | 2001-12-20 | |||
| US6172081B1 | 2001-01-09 | |||
| WO2000034241A1 | 2000-06-15 |
Other References:
JPN6009058450, ＡＳＨＷＯＲＴＨ，Ｄ．Ｍ． ｅｔ ａｌ．, "４−Ｃｙａｎｏｔｈｉａｚｏｌｉｄｉｄｅｓ ａｓ ｖｅｒｙ ｐｏｔｅｎｔ， ｓｔａｂｌｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｄｉｐｅｐｔｉｄｙｌ ｐｅｐｔｉｄａｓｅ ＩＶ", Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 1996, Ｖｏｌ．６， Ｎｏ．２２, ｐ．２７４５−２７４８
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura