HIVに対する強化された免疫応答を誘導する方法

Japanese Patent JP2006503800

A

An efficient means of inducing an immune response against human immunodeficiency virus ("HIV") utilizing specific prime-boost regimes is disclosed. The specific prime-boost regimes employ a heterologous prime-boost protocol wherein recombinant adenoviral and poxvirus vectors comprising exogenous genetic material encoding a common HIV antigen are administered in that order. Vaccines administered into living vertebrate tissue in accordance with the disclosed regimes, preferably a mammalian host such as a human or a non-human mammal of commercial or domestic veterinary importance, express the HIV-1 antigen (e.g., Gag), inducing a cellular immune response which specifically recognizes HIV-1. It is believed that the disclosed prime/boost regime will offer a prophylactic advantage to previously uninfected individuals and/or provide a therapeutic effect by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV-1 infection.

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Eminee, Emilio A
Shiver, Jiyeon Davryu
Chyastein, Michael
Casimiro, Danilo Earl
Fu, Dong Min
Lian, Xiaopin

JP2003574805A

February 02, 2006

March 12, 2003

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MERCK & COMPANY INCOPORATED

A61K35/76; A61K39/21; A61K48/00; A61P31/18; A61P37/02; C07K14/16; C12N15/09; C12N15/861; C12N15/863; A61K39/00

Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura

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