Title:
血管透過性亢進を阻害する方法
Document Type and Number:
Japanese Patent JP2006506321
Kind Code:
A
Abstract:
The present invention relates to methods for decreasing or inhibiting disorders associated with vascular hyperpermeability and to methods of screening for compounds that affect permeability, angiogenesis and stabilize tight junctions. In one aspect of the present invention there is provided a method of decreasing or inhibiting vascular hyperpermeability in an individual in need of such treatment. The method includes administering to the individual an effective amount of an antiangiogenic compound selected from the group consisting of endostatin, thrombospondin, angiostatin, tumstatin, arrestin, recombinant EPO and polymer conjugated TNP-470. Other antiangiogenic compounds are disclosed herein.
Inventors:
Soaker shy
Stachi-Finalonit
Stachi-Finalonit
Application Number:
JP2003583209A
Publication Date:
February 23, 2006
Filing Date:
April 11, 2003
Export Citation:
Assignee:
Children's Medical Center Corporation
International Classes:
A61K38/00; A61K38/17; A61K38/21; A61K38/22; A61K38/54; A61K45/00; A61K49/00; A61P7/00; A61P7/10; A61P9/00; A61P9/10; A61P13/12; A61P17/06; G01N33/15; G01N33/50; A61B
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi