Title:
オリゴヌクレオチド結合体
Document Type and Number:
Japanese Patent JP2006507812
Kind Code:
A
Abstract:
Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
Inventors:
Gryaznov Sergey
Pon Graz Christina
Tollman Richard Elle.
Morin Greg Bee.
Pon Graz Christina
Tollman Richard Elle.
Morin Greg Bee.
Application Number:
JP2004540144A
Publication Date:
March 09, 2006
Filing Date:
September 23, 2003
Export Citation:
Assignee:
GERON CORPORATION
International Classes:
C12N15/09; A61K31/7125; A61P35/00; A61P43/00; C07H21/00; C12N9/99
Domestic Patent References:
| JP2005508634A | 2005-04-07 | |||
| JP2001524100A | 2001-11-27 | |||
| JP2002523335A | 2002-07-30 |
Foreign References:
| WO2001018015A1 | 2001-03-15 | |||
| WO1996023508A1 | 1996-08-08 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi