Title:
ジヒドロ-ジベンゾ(A)アントラセンの誘導体および選択的エストロゲン受容体モジュレータとしてのその使用
Document Type and Number:
Japanese Patent JP2006508066
Kind Code:
A
Abstract:
The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C2-C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; X is S- or -HC-CH-; and Y is O-, -S-, -NH-, -NMe-, or -CH2-; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen
Inventors:
Owen Brendan Wallace
Application Number:
JP2004539841A
Publication Date:
March 09, 2006
Filing Date:
September 22, 2003
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
C07D295/08; A61K31/4453; A61K31/4535; A61P3/06; A61P5/30; A61P9/02; A61P15/12; A61P19/08; A61P19/10; C07D295/092; C07D333/50; C07D333/76
Attorney, Agent or Firm:
Kyousei Tamura
Hiromitsu Takayama
Minato Saito
Hiromitsu Takayama
Minato Saito