Title:
合成ヘパリン結合成長因子類似体
Document Type and Number:
Japanese Patent JP2006509730
Kind Code:
A
Abstract:
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
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Inventors:
Pena, Lewis, A.
Zamora, Paul, Oh.
Lynn, Sinhwa
Grass, Joan, Dee.
Zamora, Paul, Oh.
Lynn, Sinhwa
Grass, Joan, Dee.
Application Number:
JP2004529777A
Publication Date:
March 23, 2006
Filing Date:
August 20, 2003
Export Citation:
Assignee:
Biosurface Engineering Technologies, Inc.
Broke Haven Science Associate, LRC
Broke Haven Science Associate, LRC
International Classes:
C07K14/475; A61L27/00; A61L27/34; A61L33/10; C07H21/04; C07K7/06; C07K7/08; C07K14/50; C07K14/52; C07K19/00; C12N5/071; A61K38/00
Foreign References:
| WO2000018921A2 | 2000-04-06 | |||
| WO2000018921A2 | 2000-04-06 |
Attorney, Agent or Firm:
Takenori Hiroe
Kenichi Uno
Takanobu Takekawa
High Shinichi Ara
Nakamura Shigenori
Kenichi Uno
Takanobu Takekawa
High Shinichi Ara
Nakamura Shigenori