L-γ-メチレングルタミン酸とその類似化合物の合成方法

Title:

L-γ-メチレングルタミン酸とその類似化合物の合成方法

Document Type and Number:

Japanese Patent JP2006516260

Kind Code:

A

Abstract:

A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-gamma-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.

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Inventors:

Cochat, harry
Chen, Think High
Woo, ye
Huiang, Chiuri
Wang, Jiang Yang
Vincent

Application Number:

JP2005501886A

Publication Date:

June 29, 2006

Filing Date:

October 22, 2003

Export Citation:

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Assignee:

Bionumeric Pharmaceuticals Incorporated

International Classes:

C07C227/32; C07C53/00; C07C207/00; C07C227/22; C07C229/00; C07C229/24; C07D209/46; C07B53/00; C07C229/30; C07D207/38; A61K

Domestic Patent References:

JPH04505932A

1992-10-15

Foreign References:

US5550128A

1996-08-27

Other References:

JPN7010000864, Ｃ．　Ｍ．　ＭＯＯＤＹ　ｅｔ　ａｌ, Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ　Ｐｅｒｋｉｎ　Ｔｒａｎｓａｃｔｉｏｎｓ　１, 1997, （２３）, ｐｐ．３５１９−３５３０
JPN6010015912, Ｊ．　ＥＺＱＵＥＲＲＡ　ｅｔ　ａｌ．, Ｔｅｔｒａｈｅｄｒｏｎ：　Ａｓｙｍｍｅｔｒｙ, 1994, ５（５）, ｐｐ．９２１−９２６
JPN6010015914, Ｓ．　Ｒ．　ＢＡＫＥＲ　ｅｔ　ａｌ．, Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ, 2000, １０（１６）, ｐｐ．１８０７−１８１０

Attorney, Agent or Firm:

Mitsuo Kata
Yoshiyuki Osuga

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