Title:
アデノウイルス血清型34ベクター、核酸及びそれにより生産されるウイルス
Document Type and Number:
Japanese Patent JP2006521089
Kind Code:
A
Abstract:
Adenoviral serotypes differ in their natural tropism. The various serotypes of adenovirus have been found to differ in at least their capsid proteins (e.g., penton-base and hexon proteins), proteins responsible for cell binding (e.g, fiber proteins), and proteins involved in adenovirus replication. This difference in tropism and capsid proteins among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins. The present invention bypasses such requirement for capsid protein modification as it presents a recombinant, replication-defective adenovirus of serotype 34, a rare adenoviral serotype, and methods for generating the alternative, recombinant adenovirus. Additionally, means of employing the recombinant adenovirus for the delivery and expression of exogenous genes are provided.
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Inventors:
Eminee, Emilio A
Shiver, Jiyeon Davryu
BETTO, Andrew Jei
Casimiro, Danilo Earl
Kaslow, David Sea
Chyastein, Michael
Shiver, Jiyeon Davryu
BETTO, Andrew Jei
Casimiro, Danilo Earl
Kaslow, David Sea
Chyastein, Michael
Application Number:
JP2004571438A
Publication Date:
September 21, 2006
Filing Date:
August 21, 2003
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K48/00; A61P31/18; C07K14/16; C12N5/10; C12N7/04; C12N15/33; C12N15/861; A61K39/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura