Title:
化合物
Document Type and Number:
Japanese Patent JP2006521338
Kind Code:
A
Abstract:
There is provided a compound of Formula I
wherein (I) R 1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R 2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH 2 - or -CH 2 CH 2 -, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkylheterocycle group, alkenylheterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R 1 together with R 3 provide the enol tautomer OR R 1 together with R 3 form (xii) a pyrazole wherein (a) R 4 is =N-O-alkyl or =N-O-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -O-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula
(II) R 2 is selected from groups capable of forming a hydrogen bond , a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III)R 3 is selected from -OH, =O, or a -C(=O)- mimetic
Inventors:
Vicker, Nigel
Lawrence, Harsani Rismar Ruchilanani
Alan, Gillian Margaret
Christian Burbert
Fisher, Delphin Sophie Marion
Puro Hit, Alan
Reed, michael john
Potter, Barry Victor Lloyd
Lawrence, Harsani Rismar Ruchilanani
Alan, Gillian Margaret
Christian Burbert
Fisher, Delphin Sophie Marion
Puro Hit, Alan
Reed, michael john
Potter, Barry Victor Lloyd
Application Number:
JP2006505995A
Publication Date:
September 21, 2006
Filing Date:
March 22, 2004
Export Citation:
Assignee:
Sterix limited
International Classes:
C07J1/00; A61K31/56; A61K31/565; A61K31/566; A61K31/58; A61P1/02; A61P1/04; A61P1/14; A61P1/16; A61P3/10; A61P5/14; A61P5/30; A61P7/00; A61P9/10; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07J17/00; C07J33/00; C07J41/00; C07J43/00; C07J71/00; C07J
Foreign References:
| US3159656A | 1964-12-01 | |||
| US3243432A | 1966-03-29 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita