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Title:
T細胞レセプターディスプレイ
Document Type and Number:
Japanese Patent JP2006525790
Kind Code:
A
Abstract:
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identificaton of high affinity TCRs. Several high affinities are disclosed.

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Inventors:
Jacobsen, Bent, Karsten
Andersen, Torben, Bent
Molloy, Peter, Emon
Lee
Bruter, Jonathan, Michael
Application Number:
JP2005506662A
Publication Date:
November 16, 2006
Filing Date:
October 30, 2003
Export Citation:
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Assignee:
AVIDEX LIMITED
International Classes:
C12N15/09; A61K47/48; C07K14/725; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N15/10; C12Q1/02; C40B40/02; C40B40/10; G01N33/53; A61K38/00; C12Q1/70
Domestic Patent References:
JP2001514503A2001-09-11
JP2002515244A2002-05-28
Foreign References:
WO2001062908A22001-08-30
EP1118661A12001-07-25
US6080840A2000-06-27
Other References:
IMMUNITY, 1995, VOL.2, PP.281-287, JPN7009004766, ISSN: 0001454353
J. IMMUNOLOGICAL METHODS, 1998, VOL.221, PP.59-76, JPN6009056737, ISSN: 0001454354
IMMUNOLOGY, 1996, VOL.88, PP.524-530, JPN6009056733, ISSN: 0001454355
PROC. NATL. ACAD. SCI. USA, 1994, VOL.91, PP.11408-11412, JPN6011004551, ISSN: 0001834886
Attorney, Agent or Firm:
Shintaro Nogawa



 
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