アミロイド症およびそれに関連した疾患を改善するための作用物質としてのRAGEアンタゴニスト

Title:

アミロイド症およびそれに関連した疾患を改善するための作用物質としてのRAGEアンタゴニスト

Document Type and Number:

Japanese Patent JP2007503469

Kind Code:

A

Abstract:

Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition.

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Inventors:

Mali, Adnan Em. Em.
Andrews, Robert Sea.
Shen, Jane Em.
Rothrain, robert

Application Number:

JP2006533311A

Publication Date:

February 22, 2007

Filing Date:

May 20, 2004

Export Citation:

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Assignee:

TRANSTECH PHARMA,INC.

International Classes:

A61K45/00; A61K31/4164; A61K31/4184; A61K31/425; A61K38/00; A61K38/21; A61K39/395; A61K45/06; A61P25/28; A61P43/00; C07D233/64; C07D235/12

Attorney, Agent or Firm:

Yoshiyuki Kawaguchi
Hidemi Matsukura
Mayuko Wakuda
Tsutomu Toyama

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