Title:
先天性免疫のエフェクターの決定方法
Document Type and Number:
Japanese Patent JP2007505048
Kind Code:
A
Abstract:
A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
Inventors:
Hancock Robert E. W.
Finley Bee. Bullet
Scott Monisha Goff
Bow dish dawn
Rosenberger Carry Melissa
Powers John-Paul Stephen
Finley Bee. Bullet
Scott Monisha Goff
Bow dish dawn
Rosenberger Carry Melissa
Powers John-Paul Stephen
Application Number:
JP2006525585A
Publication Date:
March 08, 2007
Filing Date:
September 10, 2004
Export Citation:
Assignee:
THE UNIVERSITY OF BRITISH COLUMBIA
International Classes:
A61K38/00; A61K45/00; A61P29/00; A61P31/00; A61P31/04; A61P37/04; A61P43/00; C07K14/47; C07K14/53; C12N9/12
Domestic Patent References:
| JP2002510644A | 2002-04-09 |
Foreign References:
| WO2003048383A2 | 2003-06-12 | |||
| WO2003015809A2 | 2003-02-27 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi