Title:
1,3-ジアシル化26,27-アルキル/ハロアルキルビタミンD3化合物及びその使用方法
Document Type and Number:
Japanese Patent JP2007506765
Kind Code:
A
Abstract:
The invention provides (1,3)di-acylated vitamin D3 analogs of cholecalciferol, substituted at carbon (20) with methyl or cyclopropyl wherein carbon (16) is a single or double bond, and carbon (23) is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon (25). The invention provides pharmaceutically acceptable esters, salts, and pro-drugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.
Inventors:
Milan Earl Uskokovik
Luciano adorini
Giuseppe Penna
Enrico Colli
Hubert mayer
Luciano adorini
Giuseppe Penna
Enrico Colli
Hubert mayer
Application Number:
JP2006528227A
Publication Date:
March 22, 2007
Filing Date:
September 24, 2004
Export Citation:
Assignee:
Bioxel Esse Pia
International Classes:
C07C401/00; A61K31/59; A61K31/593; A61P1/16; A61P3/02; A61P3/04; A61P3/10; A61P5/02; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00
Attorney, Agent or Firm:
Norio Saeki